KAVOA™ kava extract is designed for products to help the overworked and stressed-out consumer. While kava promotes relaxation and stress relief, it does not induce drowsiness so it can be consumed throughout the day.
*Applied Food Sciences, Inc. does not sell products direct to consumers. This product is not to be consumed in this format but is intended for further processing or manufacturing.
What medically causes stress and other anxiety-related mental illness is not yet fully understood, but current evidence suggests mood disorders are heavily influenced by changes in g-aminobutyric acid or GABA (Sarris, 2009). GABA is a substance in the central nervous system that inhibits nerve transmission in the brain by binding to and subsequently calming neurons that have become overexcited. Herbal medicines used for the treatment of brain health, like kava, use certain mechanisms of action involving complex neuron communication. This involves specific plant metabolites binding to neurotransmitters (Spinella 2001) and alters neurotransmitter synthesis (Sarris, 2007). In the case of kava, research demonstrates that it indirectly affects GABA neurotransmission having a damping effect on stimulatory pathways, which ultimately can provide an overall calming effect on the brain, benefiting sleep, relaxation and overall mood (Sarris, 2009; Baldwin, 2005).
Baldwin, D.S., Polkinghorn, C., 2005. Evidence-based pharmacotherapy of Generalized Anxiety Disorder. Int. J. Neuropsychopharmacol. 8, 293–302
Sarris J, Kavanagh D, Byrne G, et al. The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled, cross-over trial using an aqueous extract of Piper methysticum. Psychopharmacology (Berl). 2009;205(3):399–407.
Spinella, M., 2001. The Psychopharmacology of Herbal Medicine: Plant Drugs That Alter Mind, Brain and Behavior (Paperback). MIT Press, Cambridge.
Sarris, J., 2007. Herbal medicines in the treatment of psychiatric disorders: a systematic review. Phytother. Res. 21, 703–716. Sarris, J., Byrne, G., 2011. A systematic review of insomnia and complementary medicine. Sleep Med. Rev. 15 (2), 99–106.